Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine

We aimed to determine whether the multidrug-resistance-proteins MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the antimetabolites cytarabine (Ara-C), gemcitabine (GEM), and the L-nucleoside analog troxacitabine. For this purpose we used HEK293 and the transfected HEK/MRP4 (59-fold increased MRP...

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Bibliografske podrobnosti
izdano v:Springerplus
Main Authors: Adema, Auke D, Floor, Karijn, Smid, Kees, Honeywell, Richard J, Scheffer, George L, Jansen, Gerrit, Peters, Godefridus J
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2014
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320143/
https://ncbi.nlm.nih.gov/pubmed/25674464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2193-1801-3-732
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