Inhalable delivery of AAV-based MRP4/ABCC4 silencing RNA prevents monocrotaline-induced pulmonary hypertension

The ATP-binding cassette transporter MRP4 (encoded by ABCC4) regulates membrane cyclic nucleotides concentrations in arterial cells including smooth muscle cells. MRP4/ABCC4 deficient mice display a reduction in smooth muscle cells proliferation and a prevention of pulmonary hypertension in response...

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Udgivet i:Mol Ther Methods Clin Dev
Main Authors: Claude, Caroline, Mougenot, Nathalie, Bechaux, Julia, Hadri, Lahouaria, Brockschnieder, Damian, Clergue, Michel, Atassi, Fabrice, Lompré, Anne-Marie, Hulot, Jean-Sébastien
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449024/
https://ncbi.nlm.nih.gov/pubmed/26052533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.65
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