Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model

BACKGROUND: Pulmonary hypertension (PH) is characterized by pulmonary arterial remodeling that results in increased pulmonary vascular resistance, right ventricular (RV) failure, and premature death. Down-regulation of sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) in the pulmonary vasculature le...

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發表在:J Am Coll Cardiol
Main Authors: Aguero, Jaume, Ishikawa, Kiyotake, Hadri, Lahouaria, Santos-Gallego, Carlos G., Fish, Kenneth M., Kohlbrenner, Erik, Hammoudi, Nadjib, Kho, Changwon, Lee, Ahyoung, Ibáñez, Borja, García-Alvarez, Ana, Zsebo, Krisztina, Maron, Bradley A., Plataki, Maria, Fuster, Valentin, Leopold, Jane A., Hajjar, Roger J.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019268/
https://ncbi.nlm.nih.gov/pubmed/27126531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2016.02.049
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