Therapeutic Efficacy of AAV1.SERCA2a in Monocrotaline-Induced Pulmonary Arterial Hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) is characterized by dysregulated proliferation of pulmonary artery smooth muscle cells leading to (mal)adaptive vascular remodeling. In the systemic circulation, vascular injury is associated with downregulation of sarcoplasmic reticulum Ca(2+)-ATPas...

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Main Authors: Hadri, Lahouaria, Kratlian, Razmig G., Benard, Ludovic, Maron, Bradley A., Dorfmüller, Peter, Ladage, Dennis, Guignabert, Christophe, Ishikawa, Kiyotake, Aguero, Jaume, Ibanez, Borja, Turnbull, Irene C., Kohlbrenner, Erik, Liang, Lifan, Zsebo, Krisztina, Humbert, Marc, Hulot, Jean-Sébastien, Kawase, Yoshiaki, Hajjar, Roger J., Leopold, Jane A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908449/
https://ncbi.nlm.nih.gov/pubmed/23804254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.001585
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