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Variegated transgene expression in mouse mammary gland is determined by the transgene integration locus.

Mice carrying an ovine beta-lactoglobulin (BLG) transgene secrete BLG protein into their milk. To explore transgene expression stability, we studied expression levels in three BLG transgenic mouse lines. Unexpectedly, two lines exhibited variable levels of transgene expression. Copy number within li...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Dobie, K W, Lee, M, Fantes, J A, Graham, E, Clark, A J, Springbett, A, Lathe, R, McClenaghan, M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
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Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39082/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692874/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.13.6659
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