Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

We performed in vivo and in vitro studies to determine the induction of human cytochrome P450 (CYP) using chimeric mice with humanized liver (PXB-mice(®)) and human hepatocytes isolated from the PXB-mice (PXB-cells), which were derived from the same donor. For the in vivo study, PXB-mice were inject...

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Hlavní autoři: Kakuni, Masakazu, Yamasaki, Chihiro, Tachibana, Asato, Yoshizane, Yasumi, Ishida, Yuji, Tateno, Chise
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Diversity Preservation International (MDPI) 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907798/
https://ncbi.nlm.nih.gov/pubmed/24362577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms15010058
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