Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

Human hepatocytes were transplanted into urokinase-type plasminogen activator-transgenic SCID mice (uPA/SCID mice), which are immunodeficient and undergo liver failure. The transplanted cells were characterized in terms of their in vivo growth potential and functions. The human hepatocytes progressi...

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Hauptverfasser: Tateno, Chise, Yoshizane, Yasumi, Saito, Naomi, Kataoka, Miho, Utoh, Rie, Yamasaki, Chihiro, Tachibana, Asato, Soeno, Yoshinori, Asahina, Kinji, Hino, Hiroshi, Asahara, Toshimasa, Yokoi, Tsuyoshi, Furukawa, Toshinori, Yoshizato, Katsutoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2004
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618591/
https://ncbi.nlm.nih.gov/pubmed/15331414
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