MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells

Blasts from approximately one-third of patients with acute myeloid leukemia (AML) harbor activating mutations in the FMS-like tyrosine kinase 3 (FLT3) receptor tyrosine kinase that confer a poor prognosis. The Mucin 1-C-terminal subunit (MUC1-C) oncoprotein is aberrantly expressed in AML blasts and...

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Detalhes bibliográficos
Main Authors: Liu, Suiyang, Yin, Li, Stroopinsky, Dina, Rajabi, Hasan, Puissant, Alexandre, Stegmaier, Kimberly, Avigan, David, Kharbanda, Surender, Kufe, Donald, Stone, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907758/
https://ncbi.nlm.nih.gov/pubmed/24282218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-493858
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