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Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein
Chronic myelogenous leukemia (CML) is caused by expression of the Bcr-Abl fusion protein in hematopoietic stem cells. The MUC1-C oncoprotein is expressed in CML blasts and stabilizes Bcr-Abl. The present studies demonstrate that treatment of KU812 and K562 CML cells with GO-201, a cell-penetrating p...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034602/ https://ncbi.nlm.nih.gov/pubmed/20592495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.5.12584 |
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