Aberrantly spliced HTT, a new player in Huntington’s disease pathogenesis

Huntington’s disease (HD) is an adult-onset neurodegenerative disorder caused by a mutated CAG repeat in the huntingtin gene that is translated into an expanded polyglutamine tract. The clinical manifestation of HD is a progressive physical, cognitive, and psychiatric deterioration that is eventuall...

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Hlavní autoři: Gipson, Theresa A, Neueder, Andreas, Wexler, Nancy S, Bates, Gillian P, Housman, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907474/
https://ncbi.nlm.nih.gov/pubmed/24256709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.26706
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