Analysis of Spatial Correlations Between Patterns of DNA Damage Response and DNA Replication in Nuclei of Cells Subjected to Replication Stress or Oxidative Damage

Sites of DNA replication (EdU incorporation) and DNA damage signaling (γH2AX) induced by camptothecin (Cpt) or hydrogen peroxide (H(2)O(2)) form characteristic patterns of foci in cell nuclei. The overlap between these patterns is a function of the number of DNA double strand breaks (DSBs) formed in...

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Hauptverfasser: Bernas, Tytus, Berniak, Krzysztof, Rybak, Paulina, Zarębski, Mirosław, Zhao, Hong, Darzynkiewicz, Zbigniew, Dobrucki, Jerzy W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907470/
https://ncbi.nlm.nih.gov/pubmed/23900967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.a.22325
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