Relationship of DNA Damage Signaling to DNA Replication Following Treatment with DNA Topoisomerase Inhibitors Camptothecin/Topotecan, Mitoxantrone, or Etoposide

DNA topoisomerase I (Top1) and topoisomerase II (Top2) inhibitors are widely used to treat a variety of cancers. Their mechanism of action involves stabilization of otherwise transient (“cleavable”) complexes between Top1 or Top2 and DNA; collisions of DNA replication forks with such stabilized comp...

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Main Authors: Zhao, Hong, Rybak, Paulina, Dobrucki, Jurek, Traganos, Frank, Darzynkiewicz, Zbigniew
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242513/
https://ncbi.nlm.nih.gov/pubmed/22140093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.a.21172
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