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Analysis of Spatial Correlations Between Patterns of DNA Damage Response and DNA Replication in Nuclei of Cells Subjected to Replication Stress or Oxidative Damage

Sites of DNA replication (EdU incorporation) and DNA damage signaling (γH2AX) induced by camptothecin (Cpt) or hydrogen peroxide (H(2)O(2)) form characteristic patterns of foci in cell nuclei. The overlap between these patterns is a function of the number of DNA double strand breaks (DSBs) formed in...

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Bibliografski detalji
Glavni autori: Bernas, Tytus, Berniak, Krzysztof, Rybak, Paulina, Zarębski, Mirosław, Zhao, Hong, Darzynkiewicz, Zbigniew, Dobrucki, Jerzy W.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907470/
https://ncbi.nlm.nih.gov/pubmed/23900967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.a.22325
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