De Novo Prediction of PTBP1 Binding and Splicing Targets Reveals Unexpected Features of Its RNA Recognition and Function

The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences. This variation makes it difficult to evaluate PTBP1 binding to particular sites based on sequence al...

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Bibliographic Details
Main Authors: Han, Areum, Stoilov, Peter, Linares, Anthony J., Zhou, Yu, Fu, Xiang-Dong, Black, Douglas L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907290/
https://ncbi.nlm.nih.gov/pubmed/24499931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003442
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