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The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
We show that the splicing regulator PTBP2 controls a genetic program essential for neuronal maturation. Depletion of PTBP2 in developing mouse cortex leads to degeneration of these tissues over the first three postnatal weeks, a time when the normal cortex expands and develops mature circuits. Cultu...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896118/ https://ncbi.nlm.nih.gov/pubmed/24448406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01201 |
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