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The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
BACKGROUND: The tumor suppressor protein p53 is activated by cellular stress. DNA double strand breaks (DSBs) induce the activation of the kinase ATM, which stabilizes p53 and activates its transcriptional activity. Single cell analysis revealed that DSBs induced by gamma irradiation trigger p53 acc...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3906995/ https://ncbi.nlm.nih.gov/pubmed/24252182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-11-114 |
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