Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

DNA damage initiates a series of p53 pulses. Although much is known about the interactions surrounding p53, little is known about which interactions contribute to p53’s dynamical behavior. The simplest explanation is that these pulses are oscillations intrinsic to the p53/Mdm2 negative feedback loop...

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Bibliographic Details
Main Authors: Batchelor, Eric, Mock, Caroline, Bhan, Irun, Loewer, Alexander, Lahav, Galit
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579769/
https://ncbi.nlm.nih.gov/pubmed/18471974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.03.016
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