Novel Germline Mutation in the Transmembrane Domain of HER2 in Familial Lung Adenocarcinomas

We encountered a family of Japanese descent in which multiple members developed lung cancer. Using whole-exome sequencing, we identified a novel germline mutation in the transmembrane domain of the human epidermal growth factor receptor 2 (HER2) gene (G660D). A novel somatic mutation (V659E) was als...

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Autors principals: Yamamoto, Hiromasa, Higasa, Koichiro, Sakaguchi, Masakiyo, Shien, Kazuhiko, Soh, Junichi, Ichimura, Koichi, Furukawa, Masashi, Hashida, Shinsuke, Tsukuda, Kazunori, Takigawa, Nagio, Matsuo, Keitaro, Kiura, Katsuyuki, Miyoshi, Shinichiro, Matsuda, Fumihiko, Toyooka, Shinichi
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Brief Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906987/
https://ncbi.nlm.nih.gov/pubmed/24317180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djt338
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