Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem cell–like Properties in Cancer Cells

Acquired resistance to EGF receptor (EGFR) tyrosine kinase inhibitor (TKI) is a critical problem in the treatment of lung cancer. Although several mechanisms have been shown to be responsible for acquired resistance, all mechanisms have not been uncovered. In this study, we investigated the molecula...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Shien, Kazuhiko, Toyooka, Shinichi, Yamamoto, Hiromasa, Soh, Junichi, Jida, Masaru, Thu, Kelsie L., Hashida, Shinsuke, Maki, Yuho, Ichihara, Eiki, Asano, Hiroaki, Tsukuda, Kazunori, Takigawa, Nagio, Kiura, Katsuyuki, Gazdar, Adi F., Lam, Wan L., Miyoshi, Shinichiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506773/
https://ncbi.nlm.nih.gov/pubmed/23542356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4136
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