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Antibiotic-free production of a herpes simplex virus 2 DNA vaccine in a high yield cGMP process

Two DNA vaccine plasmids encoding Herpes simplex virus type 2 (HSV-2) glycoprotein D, NTC8485-O2-gD2 and NTC8485-O2-UgD2tr, were produced at large scale under current good manufacturing practice (cGMP) for use in a Phase I human clinical trial. These DNA vaccines incorporate the regulatory agency co...

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Bibliografiske detaljer
Main Authors: Nelson, Jared, Rodriguez, Stephen, Finlayson, Neil, Williams, Jim, Carnes, Aaron
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906406/
https://ncbi.nlm.nih.gov/pubmed/23899469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.25048
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