NF-κB activation during intradermal DNA vaccination is essential for eliciting tumor protective antigen-specific CTL responses

DNA vaccines have been shown to elicit tumor-protective cytotoxic T lymphocyte (CTL) immunity in preclinical models, but have shown limited efficacy in cancer patients. Plasmids used for DNA vaccines can stimulate several innate immune receptors, triggering the activation of master transcription fac...

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Autors principals: Ligtenberg, Maarten A, Rojas-Colonelli, Nicole, Kiessling, Rolf, Lladser, Alvaro
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906403/
https://ncbi.nlm.nih.gov/pubmed/23884215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.25699
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