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Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects
Manufacturing-induced disulfide reduction has recently been reported for monoclonal human immunoglobulin gamma (IgG) antibodies, a widely used modality in the biopharmaceutical industry. This effect has been tied to components of the intracellular thioredoxin reduction system that are released upon...
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| Главные авторы: | , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3906314/ https://ncbi.nlm.nih.gov/pubmed/23751615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24725 |
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