Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects

Manufacturing-induced disulfide reduction has recently been reported for monoclonal human immunoglobulin gamma (IgG) antibodies, a widely used modality in the biopharmaceutical industry. This effect has been tied to components of the intracellular thioredoxin reduction system that are released upon...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hutterer, Katariina M., Hong, Robert W., Lull, Jonathon, Zhao, Xiaoyang, Wang, Tian, Pei, Rex, Le, M. Eleanor, Borisov, Oleg, Piper, Rob, Liu, Yaoqing Diana, Petty, Krista, Apostol, Izydor, Flynn, Gregory C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2013
Pynciau:
Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906314/
https://ncbi.nlm.nih.gov/pubmed/23751615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24725
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