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E2 enzyme inhibition by stabilization of a low affinity interface with ubiquitin
Weak protein interactions between ubiquitin and the ubiquitin-proteasome system (UPS) enzymes that mediate its covalent attachment to substrates serve to position ubiquitin for optimal catalytic transfer. We show that a small molecule inhibitor of the E2 ubiquitin conjugating enzyme Cdc34A, called C...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905752/ https://ncbi.nlm.nih.gov/pubmed/24316736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1412 |
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