Structural basis of AMPK regulation by small molecule activators

AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Binding of AMP causes allosteric activation of the enzyme and binding of either AMP or ADP promotes and maintains the phosphor...

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Main Authors: Xiao, Bing, Sanders, Matthew J., Carmena, David, Bright, Nicola J., Haire, Lesley F., Underwood, Elizabeth, Patel, Bhakti R., Heath, Richard B., Walker, Philip A., Hallen, Stefan, Giordanetto, Fabrizio, Martin, Stephen R., Carling, David, Gamblin, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905731/
https://ncbi.nlm.nih.gov/pubmed/24352254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4017
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