Structural basis of AMPK regulation by small molecule activators

AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Binding of AMP causes allosteric activation of the enzyme and binding of either AMP or ADP promotes and maintains the phosphor...

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Bibliografiska uppgifter
Huvudupphovsmän: Xiao, Bing, Sanders, Matthew J., Carmena, David, Bright, Nicola J., Haire, Lesley F., Underwood, Elizabeth, Patel, Bhakti R., Heath, Richard B., Walker, Philip A., Hallen, Stefan, Giordanetto, Fabrizio, Martin, Stephen R., Carling, David, Gamblin, Steven J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Pub. Group 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905731/
https://ncbi.nlm.nih.gov/pubmed/24352254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4017
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