Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β–dependent cancer metastasis

A key feature of TGF-β signaling activation in cancer cells is the sustained activation of SMAD complexes in the nucleus; however, the drivers of SMAD activation are poorly defined. Here, using human and mouse breast cancer cell lines, we found that oncogene forkhead box M1 (FOXM1) interacts with SM...

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Main Authors: Xue, Jianfei, Lin, Xia, Chiu, Wen-Tai, Chen, Yao-Hui, Yu, Guanzhen, Liu, Mingguang, Feng, Xin-Hua, Sawaya, Raymond, Medema, René H., Hung, Mien-Chie, Huang, Suyun
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904622/
https://ncbi.nlm.nih.gov/pubmed/24382352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71104
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