TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis

The mechanisms by which TGF-β promotes lung adenocarcinoma (ADC) metastasis are largely unknown. Here, we report that in lung ADC cells, TGF-β potently induces expression of DOCK4, but not other DOCK family members, via the Smad pathway and that DOCK4 induction mediates TGF-β’s prometastatic effects...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Yu, Jia-Ray, Tai, Yilin, Jin, Ying, Hammell, Molly C., Wilkinson, J. Erby, Roe, Jae-Seok, Vakoc, Christopher R., Van Aelst, Linda
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2015
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318142/
https://ncbi.nlm.nih.gov/pubmed/25644601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.248963.114
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