Sequence-dependent termination of in vitro DNA synthesis by cis- and trans-diamminedichloroplatinum (II).

Inhibition of DNA replication by the antitumor drug cis-diamminedichloroplatinum (II) (cis-DDP) has been proposed to be responsible for its cytotoxicity. Treatment of primed phage M13 mp8 viral DNA templates with the drug followed by second-strand synthesis using large fragment DNA polymerase I reve...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Pinto, A L, Lippard, S J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1985
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390436/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3895221/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.14.4616
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