R-(−)–gossypol (AT-101) activates programmed cell death in multiple myeloma cells

OBJECTIVE: Bcl-2 family proteins play a critical role in malignancies by regulating the balance between cell survival and apoptosis. R-(−)–gossypol (AT-101) is a small molecule that mimics the BH3 domain of cellular Bcl-2 inhibitors and interferes with the function of prosurvival Bcl-2 proteins. We...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Kline, Michael P., Rajkumar, S. Vincent, Timm, Michael M., Kimlinger, Teresa K., Haug, Jessica L., Lust, John A., Greipp, Philip R., Kumar, Shaji
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904353/
https://ncbi.nlm.nih.gov/pubmed/18346839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2008.01.003
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars