R-(−)–gossypol (AT-101) activates programmed cell death in multiple myeloma cells

OBJECTIVE: Bcl-2 family proteins play a critical role in malignancies by regulating the balance between cell survival and apoptosis. R-(−)–gossypol (AT-101) is a small molecule that mimics the BH3 domain of cellular Bcl-2 inhibitors and interferes with the function of prosurvival Bcl-2 proteins. We...

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Detalhes bibliográficos
Main Authors: Kline, Michael P., Rajkumar, S. Vincent, Timm, Michael M., Kimlinger, Teresa K., Haug, Jessica L., Lust, John A., Greipp, Philip R., Kumar, Shaji
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904353/
https://ncbi.nlm.nih.gov/pubmed/18346839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2008.01.003
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