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The story of stolen chaperones: How overexpression of Q/N proteins cures yeast prions
Prions are self-seeding alternate protein conformations. Most yeast prions contain glutamine/asparagine (Q/N)-rich domains that promote the formation of amyloid-like prion aggregates. Chaperones, including Hsp104 and Sis1, are required to continually break these aggregates into smaller “seeds.” Decr...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904315/ https://ncbi.nlm.nih.gov/pubmed/23924684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.26021 |
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