Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization

Kinase domain mutations of the epidermal growth factor receptor (EGFR) are common oncogenic events in lung adenocarcinoma. Here we explore the dependency upon asymmetric dimerization of the kinase domain for activation of lung cancer-derived EGFR mutants. We show that while wild-type EGFR and the L8...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Cho, Jeonghee, Chen, Liang, Sangji, Naveen, Okabe, Takafumi, Yonesaka, Kimio, Francis, Joshua M., Flavin, Richard J., Johnson, William, Kwon, Jihyun, Yu, Soyoung, Greulich, Heidi E., Johnson, Bruce E., Eck, Michael J., Jänne, Pasi A., Wong, Kwok-Kin, Meyerson, Matthew
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903789/
https://ncbi.nlm.nih.gov/pubmed/24063894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1145
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi