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Cetuximab/C225 -Induced Intracellular Trafficking of EGF Receptor
The monoclonal antibody C225 interacts with the ectodomain of the EGF receptor to block ligand binding and initiates receptor endocytosis and intracellular trafficking. The data herein show that C225-dependent EGF receptor trafficking relocalizes the receptor to the endoplasmic reticulum (ER) and nu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2753411/ https://ncbi.nlm.nih.gov/pubmed/19602593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0049 |
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