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The gene dosage of class Ia PI3K dictates the development of PTEN hamartoma tumor syndrome
The PTEN hamartoma tumor syndrome (PHTS) is a complex disorder caused by germline inactivating mutations of the tumor suppressor gene PTEN. Loss of PTEN function leads to unimpeded phosphatidylinositol-3′-kinase (PI3K) activity and PI3K-driven cell division. Individuals with PHTS develop benign hama...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Landes Bioscience
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3903710/ https://ncbi.nlm.nih.gov/pubmed/24131925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26812 |
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