Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity

Double-stranded oligonucleotides (ODNs) containing the consensus binding sequence of a transcription factor provide a rationally designed tool to manipulate gene expression at the transcriptional level by the decoy approach. However, modifications introduced into oligonucleotides to increase stabili...

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Detalhes bibliográficos
Main Authors: Crinelli, Rita, Bianchi, Marzia, Gentilini, Lucia, Palma, Linda, Sørensen, Mads D., Bryld, Torsten, Babu, Ravindra B., Arar, Khalil, Wengel, Jesper, Magnani, Mauro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC390358/
https://ncbi.nlm.nih.gov/pubmed/15051810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh503
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