Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets

BACKGROUND: DNAzymes cleave at predetermined sequences within RNA. A prerequisite for cleavage is that the DNAzyme can gain access to its target, and thus the DNAzyme must be capable of unfolding higher-order structures that are present in the RNA substrate. However, in many cases the RNA target seq...

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Detalhes bibliográficos
Main Authors: Vester, Birte, Hansen, Lykke H, Bo Lundberg, Lars, Babu, B Ravindra, Sørensen, Mads D, Wengel, Jesper, Douthwaite, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501032/
https://ncbi.nlm.nih.gov/pubmed/16753066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-7-19
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