Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities

Triplex-forming oligonucleotides (TFOs) are powerful tools to interfere sequence-specifically with DNA-associated biological functions. (A/T,G)-containing TFOs are more commonly used in cells than (T,C)-containing TFOs, especially C-rich sequences; indeed the low intracellular stability of the non-c...

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Hauptverfasser: Brunet, Erika, Corgnali, Maddalena, Perrouault, Loïc, Roig, Victoria, Asseline, Ulysse, Sørensen, Mads D., Babu, B. Ravindra, Wengel, Jesper, Giovannangeli, Carine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181241/
https://ncbi.nlm.nih.gov/pubmed/16049028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki726
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