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Targeting chromosomal sites with locked nucleic acid-modified triplex-forming oligonucleotides: study of efficiency dependence on DNA nuclear environment

Triplex-forming oligonucleotides (TFOs) are synthetic DNA code-reading molecules that have been demonstrated to function to some extent in chromatin within cell nuclei. Here we have investigated the impact of DNA nuclear environment on the efficiency of TFO binding. For this study we have used locke...

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Bibliografiske detaljer
Main Authors: Brunet, Erika, Corgnali, Maddalena, Cannata, Fabio, Perrouault, Loïc, Giovannangeli, Carine
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636373/
https://ncbi.nlm.nih.gov/pubmed/16951289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl630
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