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A conformational change in TFIIB is required for activator-mediated assembly of the preinitiation complex

TFIIB plays a pivotal role during assembly of the RNA polymerase II transcription preinitiation complex. TFIIB is composed of two domains that engage in an intramolecular interaction that can be disrupted by the VP16 activation domain. In this study, we describe a novel human TFIIB derivative harbou...

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Hlavní autoři: Glossop, James A., Dafforn, Tim R., Roberts, Stefan G. E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC390344/
https://ncbi.nlm.nih.gov/pubmed/15037660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh504
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