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Overexpression of the Neuritotrophic Cytokine S100β Precedes the Appearance of Neuritic β-Amyloid Plaques in APPV717F Mice

Homozygous APPV717F transgenic mice overexpress a human β-amyloid precursor protein (βAPP) mini-gene encoding a familial Alzheimer’s disease mutation. These mice develop Alzheimer-type neuritic β-amyloid plaques surrounded by astrocytes. S100β is an astrocyte-derived cytokine that promotes neurite g...

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Autors principals: Sheng, J. G., Mrak, R. E., Bales, K. R., Cordell, B., Paul, S. M., Jones, R. A., Woodward, S., Zhou, X. Q., McGinness, J. M., Griffin, W. S. T.
Format: Artigo
Idioma:Inglês
Publicat: 2000
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903403/
https://ncbi.nlm.nih.gov/pubmed/10617132
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