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Overexpression of the Neuritotrophic Cytokine S100β Precedes the Appearance of Neuritic β-Amyloid Plaques in APPV717F Mice
Homozygous APPV717F transgenic mice overexpress a human β-amyloid precursor protein (βAPP) mini-gene encoding a familial Alzheimer’s disease mutation. These mice develop Alzheimer-type neuritic β-amyloid plaques surrounded by astrocytes. S100β is an astrocyte-derived cytokine that promotes neurite g...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3903403/ https://ncbi.nlm.nih.gov/pubmed/10617132 |
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