The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by extracellular plaques containing amyloid β (Aβ)-protein and intracellular tangles containing hyperphosphorylated Tau protein. Here, we describe the generation of inducible pluripotent stem cell lines from patients...

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Hlavní autoři: Muratore, Christina R., Rice, Heather C., Srikanth, Priya, Callahan, Dana G., Shin, Taehwan, Benjamin, Lawrence N. P., Walsh, Dominic M., Selkoe, Dennis J., Young-Pearse, Tracy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049307/
https://ncbi.nlm.nih.gov/pubmed/24524897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu064
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