Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes that dephosphorylate STAT3, such as receptor protein tyrosine phosphatases, which are encoded by the PTPR gene family, represent a...

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Detalhes bibliográficos
Main Authors: Lui, Vivian Wai Yan, Peyser, Noah D., Ng, Patrick Kwok-Shing, Hritz, Jozef, Zeng, Yan, Lu, Yiling, Li, Hua, Wang, Lin, Gilbert, Breean R., General, Ignacio J., Bahar, Ivet, Ju, Zhenlin, Wang, Zhenghe, Pendleton, Kelsey P., Xiao, Xiao, Du, Yu, Vries, John K., Hammerman, Peter S., Garraway, Levi A., Mills, Gordon B., Johnson, Daniel E., Grandis, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903220/
https://ncbi.nlm.nih.gov/pubmed/24395800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319551111
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