Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes that dephosphorylate STAT3, such as receptor protein tyrosine phosphatases, which are encoded by the PTPR gene family, represent a...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Lui, Vivian Wai Yan, Peyser, Noah D., Ng, Patrick Kwok-Shing, Hritz, Jozef, Zeng, Yan, Lu, Yiling, Li, Hua, Wang, Lin, Gilbert, Breean R., General, Ignacio J., Bahar, Ivet, Ju, Zhenlin, Wang, Zhenghe, Pendleton, Kelsey P., Xiao, Xiao, Du, Yu, Vries, John K., Hammerman, Peter S., Garraway, Levi A., Mills, Gordon B., Johnson, Daniel E., Grandis, Jennifer R.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2014
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903220/
https://ncbi.nlm.nih.gov/pubmed/24395800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319551111
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