Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes that dephosphorylate STAT3, such as receptor protein tyrosine phosphatases, which are encoded by the PTPR gene family, represent a...

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Библиографические подробности
Главные авторы: Lui, Vivian Wai Yan, Peyser, Noah D., Ng, Patrick Kwok-Shing, Hritz, Jozef, Zeng, Yan, Lu, Yiling, Li, Hua, Wang, Lin, Gilbert, Breean R., General, Ignacio J., Bahar, Ivet, Ju, Zhenlin, Wang, Zhenghe, Pendleton, Kelsey P., Xiao, Xiao, Du, Yu, Vries, John K., Hammerman, Peter S., Garraway, Levi A., Mills, Gordon B., Johnson, Daniel E., Grandis, Jennifer R.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2014
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903220/
https://ncbi.nlm.nih.gov/pubmed/24395800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319551111
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