The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing

Conventional paradigm ascribes the cell proliferative function of the human oncoprotein mouse double minute2 (MDM2) primarily to its ability to degrade p53. Here we report that in the absence of p53, MDM2 induces replication stress eliciting an early S-phase checkpoint response to inhibit further fi...

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Main Authors: Frum, Rebecca A., Singh, Shilpa, Vaughan, Catherine, Mukhopadhyay, Nitai D., Grossman, Steven R., Windle, Brad, Deb, Sumitra, Deb, Swati Palit
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902934/
https://ncbi.nlm.nih.gov/pubmed/24163099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt944
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