DNA replication in progenitor cells and epithelial regeneration after lung injury requires the oncoprotein MDM2

Depletion of epithelial cells after lung injury prompts proliferation and epithelial mesenchymal transition (EMT) of progenitor cells, and this repopulates the lost epithelial layer. To investigate the cell proliferative function of human oncoprotein MDM2, we generated mouse models targeting human M...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Singh, Shilpa, Vaughan, Catherine A., Rabender, Christopher, Mikkelsen, Ross, Deb, Sumitra, Palit Deb, Swati
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824310/
https://ncbi.nlm.nih.gov/pubmed/31527309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128194
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