The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing

Conventional paradigm ascribes the cell proliferative function of the human oncoprotein mouse double minute2 (MDM2) primarily to its ability to degrade p53. Here we report that in the absence of p53, MDM2 induces replication stress eliciting an early S-phase checkpoint response to inhibit further fi...

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Hlavní autoři: Frum, Rebecca A., Singh, Shilpa, Vaughan, Catherine, Mukhopadhyay, Nitai D., Grossman, Steven R., Windle, Brad, Deb, Sumitra, Deb, Swati Palit
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902934/
https://ncbi.nlm.nih.gov/pubmed/24163099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt944
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