Biochemical and random mutagenesis analysis of the region carrying the catalytic E152 amino acid of HIV-1 integrase

HIV-1 integrase (IN) catalyzes the integration of the proviral DNA into the cellular genome. The catalytic triad D(64), D(116) and E(152) of HIV-1 IN is involved in the reaction mechanism and the DNA binding. Since the integration and substrate binding processes are not yet exactly known, we studied...

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Main Authors: Calmels, C., Richard de Soultrait, V., Caumont, A., Desjobert, C., Faure, A., Fournier, M., Tarrago-Litvak, L., Parissi, V.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2004
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC390286/
https://ncbi.nlm.nih.gov/pubmed/14999095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh298
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