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Biochemical and random mutagenesis analysis of the region carrying the catalytic E152 amino acid of HIV-1 integrase
HIV-1 integrase (IN) catalyzes the integration of the proviral DNA into the cellular genome. The catalytic triad D(64), D(116) and E(152) of HIV-1 IN is involved in the reaction mechanism and the DNA binding. Since the integration and substrate binding processes are not yet exactly known, we studied...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC390286/ https://ncbi.nlm.nih.gov/pubmed/14999095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh298 |
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