Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion

The ectonucleotidases CD39 and CD73 degrade ATP to adenosine which inhibits immune responses via the A(2A) adenosine receptor (ADORA2A) on T and NK cells. The current study investigates the potential therapeutic use of the specific anti CD39- and anti CD73-antibodies A1 (CD39) and 7G2 (CD73) as thes...

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Hlavní autoři: Häusler, Sebastian FM, del Barrio, Itsaso Montalbán, Diessner, Joachim, Stein, Roland G, Strohschein, Jenny, Hönig, Arnd, Dietl, Johannes, Wischhusen, Jörg
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902223/
https://ncbi.nlm.nih.gov/pubmed/24489992
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