JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis

Pancreatic β-cell dysfunction is central to type 2 diabetes pathogenesis. Prolonged elevated levels of circulating free-fatty acids and hyperglycemia, also termed glucolipotoxicity, mediate β-cell dysfunction and apoptosis associated with increased c-Jun N-terminal Kinase (JNK) activity. Endoplasmic...

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Bibliographische Detailangaben
Hauptverfasser: Prause, Michala, Christensen, Dan Ploug, Billestrup, Nils, Mandrup-Poulsen, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901710/
https://ncbi.nlm.nih.gov/pubmed/24475223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087067
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